Archiver > GENEALOGY-DNA > 2009-04 > 1239475175

From: Rebekah Canada <>
Subject: Re: [DNA] Current position under Haplogroup H
Date: Sat, 11 Apr 2009 13:39:35 -0500
References: <>
In-Reply-To: <>

___Talking about mtDNA___


An Unique Event Polymorphism is rather like a closed ecosystem. It
likely is not found on earth.:-) But... the defining mutation for
haplogroup H1c is 477C. So far out of about 9,000 samples in public
and private databases it is only found in H1c. Those H1cs are so

Now the important thing for understanding mtDNA is knowing that most
mutations happen many times. Mostly it is a good idea to avoid naming
a subclade using a *Hot* mutation. Sometimes they get used anyhow

Now here is an example, from GenBank, of what Dr. van Oven calls an H1a3.

GenBank ID: EF177447
Origin: Portugal
Author: Pereira (Unpublished)
Name: H1a3
HVR2: A73G A263G 315.1C C534T
Coding Region: A750G A1438G G3010A A4769G A8860G T10238C T12738C A14978G A15326G
HVR1: A16051G C16159T A16162G
A750G A1438G A4769G A8860G and A15326G are mutations that you will see
for almost all mtDNA haplogroup Hs outside of H2.

When we know that someone is an H then having 3010A is --usually-- the
defining mutation for H1.

When we know that someone is an H1 then having BOTH 73G AND 16162G
makes them an H1a.

According to van Oven, when someone is known to be an H1a and they
have 16051G then that makes them an H1a3.

There are two key parts to this though. You have to know that someone
is an H. FTDNA started SNP confirming that in 2005 for all new tests.
Next you have to know that they are an H1 that means that they must
have the mtDNA full genomic sequence to know that. Finally they must
not be one of the subclades of H that also has a parallel mutation at
3010A. Examples of where that happens are H3, H5, and H11.:-)

One of the things that Dr. Behar said at the conference is that IF you
are  an H and you want to do Genetic Genealogy then you need the mtDNA
full genomic sequence.

I will go a bit further...

If you are an H and your interest is in Anthro Genealogy, ie your more
ancient history, then you also must have the mtDNA full genomic

I hope that helps a little.

____ OH YAH____
There is a nice sale on for H and HV mtDNA full genomic sequences,
FGSs, through the 24th.... If your project member can afford it... It
is a good idea. But I am biased.;-)


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