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From: David Ewing <>
Subject: Re: [R-M222] How long has M222 been in Scotland?
Date: Thu, 26 Aug 2010 20:32:42 -0600
Sandy Paterson has just posted a link to a distribution of pair-wise genetic
distances between a goodly number of 67-marker R:M222 haplotypes. Very cool.
He has clearly shown that my speculation that most members of R:M222 would
be found to be within genetic distance 10 of one another is incorrect.
I have some questions. One is whether these are all SNP proven members of
R:M222. The others I don't expect Sandy to be able to answer off hand, and I
certainly don't expect him to calculate them, but if he had time on his
hands...
- What would the distribution look like if you looked at 37-marker
haplotypes for the same data set? My guess is that you would find that a
disproportionate amount of the distance is to be found in the 37-marker
panel.
- What is the distribution of genetic distances between these individual
haplotypes and the R:M222 modal? (for both 37 and 67-marker haplotypes) My
guess is that 90% will be within genetic distance 10 of the 37-marker modal,
and (totally grabbing this next number from the sky) 90% will be within
genetic distance 12 of the 67-marker modal.
David Ewing
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