DNA-R1B1C7-L ArchivesArchiver > DNA-R1B1C7 > 2009-12 > 1260541341
From: Iain Kennedy <>
Subject: Re: [R-M222] Coyne and Golden project families
Date: Fri, 11 Dec 2009 14:22:21 +0000
I found this Chandler post although not the maths that lies behind it:
If you match
someone 65/67 and differ by only one step on each of the discrepant
markers, the 95% confidence interval for TMRCA extends back 17
generations under "normal" circumstances. If one of the mismatches is
by two steps instead of one step, you need to add an extra generation
to the count. If you happen to be within a step or two of the modal
haplotype for your subclade, however, the time is doubled. Even if
the match is exact, 67/67, the 95% CI goes back 8 generations, and so
finding and confirming the relationship may be difficult. Of course,
if you have exactly the modal haplotype of your subclade, this time,
too, must be doubled.
> Date: Fri, 11 Dec 2009 13:23:40 +0000
> Subject: Re: [R-M222] Coyne and Golden project families
> I am well aware of the fact that the subject of DNA genetics is still in its
> infancy. I am also well aware that some people on the list are new to the
> subject and are on the list in the hope that they may learn a little and
> find things of interest.
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|Re: [R-M222] Coyne and Golden project families by Iain Kennedy <>|