DNA-R1B1C7-L Archives

Archiver > DNA-R1B1C7 > 2009-04 > 1240794493


From: "Ken Nordtvedt" <>
Subject: Re: [R-M222] Walk on the Y Project
Date: Sun, 26 Apr 2009 19:08:13 -0600
References: <e0d2d2870904261800j33e97365m8b9f4826c3dda328@mail.gmail.com>


Mutation rate 2 / 100 million
Number of nucelotide sites examined 100,000 in a walk the y search
Probability per generation of a snp occuring along a branch line is the
product: 1/500

----- Original Message -----
From: "David Ewing" <>
To: <>
Sent: Sunday, April 26, 2009 7:00 PM
Subject: Re: [R-M222] Walk on the Y Project


> Ken Nordtvedt tells us that total branch length in generations divided by
> 500 gives the odds of finding a new SNP.
>
> Knowing Ken, I do not doubt this. Still, I would like to know how he
> arrived
> at that formula. I understand that single nucleotides mutate five orders
> of
> magnitude more slowly than STRs. The mutation rate of single nucleotides
> is
> something like 0.00000002, or one per nucleotide per 50 million
> generations.
> But since there are about 60 million nucleotides in the Y-chromosome, we
> should expect a little over one new SNP per generation, on average. I have
> na idea that Ken's much smaller number results from the fact that not all
> 60
> million nucleotides are being considered, and the Walk on the Y project is
> looking at only one five-hundreth of these, but I certainly do not know.
>
> Can someone help me understand this?
>
> David Ewing
> R1b1c7 Research and Links:
>
> http://clanmaclochlainn.com/R1b1c7/
> -------------------------------
> To unsubscribe from the list, please send an email to
> with the word 'unsubscribe' without the
> quotes in the subject and the body of the message
>


This thread: