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Archiver > DNA-R1B1C7 > 2009-04 > 1240226927


From: David Ewing <>
Subject: Re: [R-M222] Byrne TMRCA Estimates
Date: Mon, 20 Apr 2009 05:28:47 -0600


I apologize for my confusion about your gender, Sandy.

Let me refer to the seven R:M222 surname modals John has posted at
http://clanmaclochlainn.com/R1b1c7/M222modals.htm

By "off-modal match" I mean markers where two different haplotypes match
each other and do not match the comparison modal haplotype. In the table
showing cited above, Mclaughlin, Doherty and Dunbar have an off-modal match
at DYS458 = 18; Ewing and McGonagle have an off-modal match at DYS19 = 15;
and, nobody matches Ewing's off-modal DYS442 = 11.

I will need to look at the table a little more--I think I will try dropping
the more rapidly mutating markers from consideration and then see if I can
construct a sensible phylogeny by inspection, but I am going to guess that
if there were an informative pattern, others would already have spotted it.

DYS391 = 10 has been a big puzzle to me within the Ewing project. About 1/3
of our R:M222 Ewings have DYS391 = 10, but most of them otherwise have
matches with the DYS391 = 11 Ewings at the five other markers where the
Ewing modal does not match the R:M222 modal. Like John, I have thought that
the ancestral value for the whole Ewing group must have been DYS391 = 11
like the R:M222 and AMH modals, but the Ewing DYS391 = 10 group has greater
variance from the Ewing modal than the Ewing DYS391 = 11 group, which
suggests to me that DYS391 = 10 is the ancestral value. I just cannot
massage my tired old brain around how to explain the appearance of so many
DYS391 = 10 values elsewhere in R:M222.

David

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