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Archiver > DNA-R1B1C7 > 2008-02 > 1203494656


From: John <>
Subject: [DNA-R1B1C7] Aging R1b1c7
Date: Tue, 19 Feb 2008 23:04:16 -0900


David,
I noticed on the 37 marker comparison that ~17.5% are within a genetic distance of 6 from the modal haplotype. It seems there's a 'sweet spot' or bell curve located at a genetic distance of 4-6 on the 37 marker comparison. What is the significance of this?

I find eleven total 37 marker matches to me in Ysearch (including the R1b1c7 modal haplotype) when restricting my search to R1b1c7, all surnames, and a genetic distance of 6. I find no 37 marker matches at a genetic distance less than 6.

John Ross

From: "David Wilson" < >
Subject: [DNA-R1B1C7] Aging R1b1c7
Date: Mon, 18 Feb 2008 11:01:35 -0800
I just worked through the nearly 400 haplotypes in the R1b1c7 project data
base in order to generate some mutation profiles that may speak to the
question of age.

Of 395 haplotypes with at least 12 markers, 365 include at least 25 markers
and 325 at least 37 markers. I ignored the 67-marker haplotypes for this
study.

The breakdowns are as follows: Note that 0 = a modal haplotype, whether of
12, 25 or 37 markers. The first column in each table is a genetic distance
from the modal haplotype that is, a mutation count. The second number is
the number of haplotypes that manifest that genetic distance.


12-marker comparisons (395 total)

0 131
1 167
2 74
3 20
4 3
_________________________________

25-marker comparisons (365 total)

0 31
1 74
2 78
3 108
4 44
5 22
6 7
7 1
________________________________

37-marker haplotypes (325 total)

0 1
1 10
2 17
3 31
4 60
5 49
6 57
7 40
8 37
9 13
10 6
11 1
12 1
13 2
__________________________________


The fact that one-third of all R1b1c7 haplotypes are modal when compared at
the 12-marker level speaks to the youth of this group. For comparison, I
found only 59 haplotypes that matched the modal values for Charles
Kerchner's R1b and subclades project, which has over 1300 members. That's 33
percent for R1b1c7, less than five percent for overall R1b. Hmmm.

I am offering this just as a data tabulation. Others here may wish to do
some mutation rate analysis to see how many generations must pass from a
founder before we see profiles among his descendants that resemble the
distributions above.

David Wilson

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