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Subject: Re: [DNA-R1B1C7] Ewing project STR clusters
Date: Sat, 2 Jun 2007 16:27:38 EDT

David,

I appreciate your e-mail. First let me say that it was never my intent to
completely solve R1b, strictly to try to decipher Sykes analysis. With that
several thoughts.

First, you are correct that the core Ewing model (VPNY2, also the string
with the 19 participants) is not present anywhere in the 1600+ samples of the
OGAP data. Your second most prevalent string (9 samples, with 390=10) isn't
present either. You're also correct in that the culprit is the Ewing 439=13.
This seems very unique to your project. There are only 6 samples in all of
Sykes data with 439=13 (2 in London, 1 in North England, 2 in Central England
and 1 in Ireland.) None match your other markers.

So how should you think about this? Well, my analysis was done with
averages and general broad based affinities. The bottom line is that the Ewings
seem to be very unique. Being so unique means some of the broad-based
conclusions of these types of population genetics just don't apply. However, being
unique may mean that with many more samples that you might be able to isolate
where the distinctive mutation occurred. However, we won't be able to do this
until a lot more original data samples are obtained.

Sorry is this wasn't the answer that your were looking for.



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